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Scientific publications

Wissenschaftliche Publikationen

Scientific publications

 

2019

Awortwe C, Bruckmueller H, Cascorbi I. Interaction of herbal products with prescribed medications: A systematic review and meta-analysis. Pharmacol Res. 2019 Jan 17;141:397-408. doi: 10.1016/j.phrs.2019.01.028. [PubMed]

Erdmann P, Bruckmueller H, Martin P, Busch D, Haenisch S, Müller J, Wiechowska-Kozlowska A, Partecke LI, Heidecke CD, Cascorbi I, Drozdzik M, Oswald S. Dysregulation of mucosal membrane transporters and drug metabolizing enzymes in ulcerative colitis. J Pharm Sci. 2019;108:1035-1046. [PubMed]

Sachau J, Bruckmueller H, Gierthmühlen J, Magerl W, Kaehler M, Haenisch S, Binder A, Caliebe A, Maier C, Treede RD, Tölle T, Cascorbi I, Baron R. SIGMA-1 receptor gene variants affect the somatosensory phenotype in neuropathic pain patients. J Pain. 2019;20:201-214. [PubMed]

Spedding M, Barrett J, Morgan ET, Vore M, Geraghty D, Kirkpatrick C, Cascorbi I. Plan S: A threat to quality of science? Science. 2019;363:462. [PubMed]
 

2018

Awortwe C, Kaehler M, Rosenkranz B, Cascorbi I, Bruckmueller H. MicroRNA-655-3p regulates Echinacea purpurea mediated activation of ABCG2. Xenobiotica. 2018;48:1050-1058. [PubMed]

Böhm R, Proksch E, Schwarz T, Cascorbi I. Drug hypersensitivity. Dtsch Arztebl Int. 2018;115:501-512. [PubMed]

Brinkman DJ, Tichelaar J, Mokkink LB, Christiaens T, Likic R, Maciulaitis R, Costa J, Sanz EJ, Maxwell SR, Richir MC, van Agtmael MA; Education Working Group of the European Association for Clinical Pharmacology and Therapeutics (EACPT) and its affiliated Network of Teachers in Pharmacotherapy (NOTIP). Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study. Clin Pharmacol Ther. 2018;104:317-325. [PubMed]

Cascorbi I.The Pharmacogenetics of Immune-Modulating Therapy. Adv Pharmacol. 2018;83:275-296. Epub 2018 Mar 30 [PubMed]

Cascorbi I. Significance of Pharmacogenomics in Precision Medicine. Clin Pharmacol Ther. 2018 May;103(5) [PubMed]

Culman J, Mühlenhoff S, Blume A, Hedderich J, Lützen U, Hunt SP, Rupniak NMJ, Zhao Y. The hypothalamic-pituitary-adrenal axis and serotonin metabolism in individual brain nuclei of mice with genetic disruption of the NK1 receptor exposed to acute stress. Cell Mol Neurobiol. 2018;38:1271-1281. [PubMed]

Hahn-Godeffroy JD, Mangold S, Bernert M, Bartelt A, Herdegen T. Langanhaltende Besserung von somatischen und psychovegetativen Störungen unter Procain-Infusionen: Eine multizentrische Anwendungsbeobachtung. Complement Med Res. 2018 Nov 24. [PubMed]

Koch A, Cascorbi I, Westhofen M, Dafotakis M, Klapa S, Kuhtz-Buschbeck JP. The neurophysiology and treatment of motion sickness. Dtsch Arztebl Int. 2018;115:687-696. [PubMed]

Standl T, Annecke T, Cascorbi I, Heller AR, Sabashnikov A, Teske W. The nomenclature, definition and distinction of types of shock. Dtsch Arztebl Int. 2018;115:757-768. [PubMed]

Waetzig V, Haeusgen W, Andres C, Frehse S, Reinecke K, Bruckmueller H, Boehm R, Herdegen T, Cascorbi I. Retinoic acid-induced survival effects in SH-SY5Y neuroblastoma cells. J Cell Biochem. 2018 Oct 15. [PubMed]

Wagener R, López C, Kleinheinz K, Bausinger J, Aukema SM, Nagel I, Toprak UH, Seufert J, Altmüller J, Thiele H, Schneider C, Kolarova J, Park J, Hübschmann D, Murga Penas EM, Drexler HG, Attarbaschi A, Hovland R, Kjeldsen E, Kneba M, Kontny U, de Leval L, Nürnberg P, Oschlies I, Oscier D, Schlegelberger B, Stilgenbauer S, Wössmann W, Schlesner M, Burkhardt B, Klapper W, Jaffe ES, Küppers R, Siebert R. IG-MYC + neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas. Blood. 2018;132:2280-2285 [PubMed]

Wagener R, Seufert J, Raimondi F, Bens S, Kleinheinz K, Nagel I, Altmüller J, Thiele H, Hübschmann D, Kohler CW, Nürnberg P, Au-Yeung R, Burkhardt B, Horn H, Leoncini L, Jaffe ES, Ott G, Rymkiewicz G, Schlesner M, Russell RB, Klapper W, Siebert R. The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma. Blood. 2018 Dec 19. [PubMed]

Zingler G, Herdegen T. We should not avoid diclofenac in the treatment of spondyloarthritis. Ann Transl Med. 2018;6 (Suppl 1):S36. [PubMed]
 

 

Significance of Pharmacogenomics in Precision Medicine.

The Pharmacogenetics of Immune-Modulating Therapy.

2017

Aukema SM, van Pel R, Nagel I, Bens S, Siebert R, Rosati S, van den Berg E, Bosga-Bouwer AG, Kibbelaar RE, Hoogendoorn M, van Imhoff GW, Kluin-Nelemans HC, Kluin PM, Nijland M. MYC expression and translocation analyses in low-grade and transformed follicular lymphoma. Histopathology. 2017 Dec;71(6):960-971. Epub 2017 Oct 17. [PubMed]

Awortwe C, Kaehler M, Rosenkranz B, Cascorbi I, Bruckmueller H. MicroRNA-655-3p regulates Echinacea purpurea mediated activation of ABCG2. Xenobiotica. 2017 Nov 2:1-9.  [Epub ahead of print]

Brinkman DJ, Tichelaar J, Mokkink LB, Christiaens T, Likic R, Maciulaitis R, Costa J, Sanz EJ, Maxwell SR, Richir MC, van Agtmael MA; Education Working Group of the European Association for Clinical Pharmacology and Therapeutics (EACPT) and its affiliated Network of Teachers in Pharmacotherapy (NOTIP)Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study.
Clin Pharmacol Ther. 2017 Dec 5. doi: 10.1002/cpt.962. [Epub ahead of print]

Bruckmueller H, Martin P, Kähler M, Haenisch S, Ostrowski M, Drozdzik M, Siegmund W, Cascorbi I, Oswald S. Clinically Relevant Multidrug Transporters Are Regulated by microRNAs along the HumanIntestine. Mol Pharm. 2017 Jul 3;14(7):2245-2253.  [PubMed] 

Cascorbi I. Pharmakogenetik Aktueller Stand – Fakten und Fiktionen. Medizinische genetik. Aus Klinik und Praxis; First Online: 27 September 2017; pp 1–7 [Springer]

Cascorbi I. Inflammation: Treatment Progress and Limitations. Clin Pharmacol Ther. 2017 Oct;102(4):564-567.  [PubMed]


Cascorbi I, Werk AN. Advances and challenges in hereditary cancer pharmacogenetics. Expert Opin Drug Metab Toxicol. 2017 Jan;13(1):73-82. [PubMed]

Culman J, Jacob T, Schuster SO, Brolund-Spaether K, Brolund L, Cascorbi I, Zhao Y, Gohlke P.  Neuroprotective effects of AT1 receptor antagonists after experimental ischemic stroke: what is important? Naunyn Schmiedebergs Arch Pharmacol. 2017 Jul 2. doi: 10.1007/s00210-017-1395-y. [Epub ahead of print]

Forstenpointner J, Förster M, May D, Hofschulte F, Cascorbi I, Wasner G, Gierthmühlen J, Baron R.  Short Report: TRPV1-polymorphism 1911 A>G alters capsaicin-induced sensory changes in healthy subjects. PLoS One. 2017 Aug 17;12(8) [PubMed] 

Meike Kaehler, Johanna Ruemenapp, Daniel Gonnermann, Inga Nagel, Oliver Bruhn, Sierk Haenisch, Ole Ammerpohl, Daniela Wesch, Ingolf Cascorbi andHenrike Bruckmueller. MicroRNA-212/ABCG2-axis contributes to development of imatinib-resistance in leukemic cells. Oncotarget, 2017, Vol. 8, (No. 54), pp: 92018-92031 [PubMed]

Mizzi C, Dalabira E, Kumuthini J, Dzimiri N, Balogh I, Başak N, Böhm R, Borg J, Borgiani P, Bozina N, Bruckmueller H, Burzynska B, Carracedo A, Cascorbi I, Deltas C, Dolzan V, Fenech A, Grech G, Kasiulevicius V, Kádaši Ľ, Kučinskas V, Khusnutdinova E, Loukas YL, Macek M Jr, Makukh H, Mathijssen R, Mitropoulos K, Mitropoulou C, Novelli G, Papantoni I, Pavlovic S, Saglio G, Sertić J, Stojiljkovic M, Stubbs AP, Squassina A, Torres M, Turnovec M, van Schaik RH, Voskarides K, Wakil SM, Werk A, Del Zompo M, Zukic B, Katsila T, Lee MT, Motsinger-Rief A, Mc Leod HL, van der Spek PJ, Patrinos GP.  Correction: A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics.
PLoS One. 2017 Feb 16;12(2). eCollection 2017. [PubMed]

Lützen U, Zhao Y, Lucht K, Zuhayra M, Hedderich J, Cascorbi I, Culman J. Activation of the cell membrane angiotensin AT2 receptors in human leiomyosarcoma cells induces differentiation and apoptosis by a PPARγ - dependent mechanism.Neoplasma. 2017;64(3):395-405. doi: 10.4149/neo_2017_310. [PubMed]

Lützen U, Zhao Y, Lucht K, Zuhayra M, Marx M, Cascorbi I, Culman J. Pioglitazone induces cell growth arrest and activates mitochondrial apoptosis in human uterine leiomyosarcoma cells by a peroxisome proliferator-activated receptor γ-independent mechanism. Naunyn Schmiedebergs Arch Pharmacol. 2017 Jan;390(1):37-48. [PubMed]

Nagel I, Bartels M, Duell J, Oberg HH, Ussat S, Bruckmueller H, Ottmann O, Pfeifer H, Trautmann H, Gökbuget N, Caliebe A, Kabelitz D, Kneba M, Horst HA, Hoelzer D, Topp MS, Cascorbi I, Siebert R, Brüggemann M. Hematopoietic stem cell involvement in BCR-ABL1-positive ALL as a potential mechanism of resistance to blinatumomab therapy. Blood. 2017 Nov 2;130(18):2027-2031.  [PubMed] 

Nicoletti P, Aithal GP, Bjornsson ES, Andrade RJ, Sawle A, Arrese M, Barnhart HX, Bondon-Guitton E, Hayashi PH, Bessone F, Carvajal A, Cascorbi I, Cirulli ET, Chalasani N, Conforti A, Coulthard SA, Daly MJ, Day CP, Dillon JF, Fontana RJ, Grove JI, Hallberg P1, Hernández N, Ibáñez L, Kullak-Ublick GA, Laitinen T, Larrey D, Lucena MI, Maitland-van der Zee AH, Martin JH, Molokhia M, Pirmohamed M, Powell EE2, Qin S, Serrano J, Stephens C, Stolz A, Wadelius M, Watkins PB, Floratos A, Shen Y, Nelson MR, Urban TJ, Daly AK; International Drug-Induced Liver Injury Consortium, Drug-Induced Liver Injury Network Investigators, and International Serious Adverse Events Consortium. Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLAand Other Genes in a Genome-Wide Association Study. Gastroenterology. 2017 Apr;152(5):1078-1089. [PubMed]

Paul U, Richter J, Stuhlmann-Laiesz C, Kreuz M, Nagel I, Horn H, Staiger AM, Aukema SM, Hummel M, Ott G, Spang R, Rosenwald A, Feller AC, Cogliatti S, Stein H, Hansmann ML, Moller P, Szczepanowski M, Burkhardt B, Pfreundschuh M, Schmitz N, Loeffler M, Trümper L, Siebert R, Klapper W. Advanced patient age at diagnosis of diffuse large B-cell lymphoma is associated with molecular characteristics including ABC-subtype and high expression of MYC.  2018 May;59(5):1213-1221. Epub 2017 Aug 25.

Waetzig V, Riffert J, Cordt J, Reinecke K, Haeusgen W, Boehm R, Cascorbi I, Herdegen T. Neurodegenerative effects of azithromycin in differentiated PC12 cells. Eur J Pharmacol. 2017 Aug 15;809:1-12. Epub 2017 May 4. [PubMed]

Waetzig V, Belzer M, Haeusgen W, Boehm R, Cascorbi I, Herdegen T. Crosstalk control and limits of physiological c-Jun N-terminal kinase activity for cell viability and neurite stability in differentiated PC12 cells. Mol Cell Neurosci. 2017 Jul;82:12-22. [PubMed]
 

 

2016

Böhm R, von Hehn L, Herdegen T, Klein HJ, Bruhn O, Petri H, Höcker J. OpenVigil FDA - Inspection of U.S. American Adverse Drug Events Pharmacovigilance Data and Novel Clinical Applications. PLoS One. 2016;11(6). [PubMed]

Bruhn O, Drerup K, Kaehler M, Haenisch S, Röder C, Cascorbi I. Length variants of the ABCB1 3'-UTR and loss of miRNA binding sites: possible consequences in regulation and pharmacotherapy resistance. Pharmacogenomics. 2016 Mar;17(4):327-40.. [PubMed]

Cascorbi I, Schwab M., Epigenetics in Drug Response. Clin Pharmacol Ther. 2016 May;99(5):468-70. [PubMed]

Dhamrait SS, Maubaret C, Pedersen-Bjergaard U, Brull DJ, Gohlke P, Payne JR, World M, Thorsteinsson B, Humphries SE, Montgomery HE. Mitochondrial uncoupling proteins regulate angiotensin-converting enzyme expression: crosstalk between cellular and endocrine metabolic regulators suggested by RNA interference and genetic studies. Inside Cell. 2016;1:70-81. [PubMed]

Haenisch S, von Rüden EL, Wahmkow H, Rettenbeck ML, Michler C, Russmann V, Bruckmueller H, Waetzig V, Cascorbi I, Potschka H. miRNA-187-3p-mediated regulation of the KCNK10/TREK-2 potassium channel in a rat epilepsy model. ACS Chem Neurosci. 2016 Nov 16;7(11):1585-1594. Epub 2016 Sep 22.[PubMed]

Horn EP, Bein B, Broch O, Iden T, Böhm R, Latz SK, Höcker J. Warming before and after epidural block before general anaesthesia for major abdominal surgery prevents perioperative hypothermia: A randomised controlled trial. Eur J Anaesthesiol. 2016;33:334-40. [PubMed]

Iden T, Horn EP, Bein B, Böhm R, Höcker J. Reply to: Zero-heat flux thermometry. Eur J Anaesthesiol. 2016;33:141-3. [PubMed]

Kaschwich M, Lützen U, Zhao Y, Tjiong A, Marx M, Haenisch S, Wiedow O, Preuss S, Culman J, Zuhayra M. Biodistribution and pharmacokinetics of the (99m)Tc labeled human elastase inhibitor, elafin, in rats. Drug Metab Pharmacokinet. 2016 Apr;31(2):146-55. [PubMed]

Legge SE, Hamshere ML, Ripke S, Pardinas AF, Goldstein JI, Rees E, Richards AL, Leonenko G, Jorskog LF; Clozapine-Induced Agranulocytosis Consortium, Chambert KD, Collier DA, Genovese G, Giegling I, Holmans P, Jonasdottir A, Kirov G, McCarroll SA, MacCabe JH, Mantripragada K, Moran JL, Neale BM, Stefansson H, Rujescu D, Daly MJ, Sullivan PF, Owen MJ, O'Donovan MC, Walters JT. Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia. Mol Psychiatry.  2016 Jul 12. doi: 10.1038/mp.2016.97. [Epub ahead of print]

Lützen U, Zhao Y, Marx M, Imme T, Assam I, Siebert FA, Culman J, Zuhayra M. Effective method of measuring the radioactivity of [131I]-capsule prior to radioiodine therapy with significant reduction of the radiation exposure to the medical staff. J Appl Clin Med Phys. 2016;17:5942. [PubMed]

M Ingelman-Sundberg and I Cascorbi, Pharmacogenomic or -Epigenomic Biomarkers in Drug Treatment: Two Sides of the Same Medal? Clin Pharmacol Ther. 2016 May;99(5):478-80. Epub 2016 Mar 29.[PubMed]

Nicoletti P, Werk AN, Sawle A, Shen Y, Urban TJ, Coulthard SA, Bjornsson ES, Cascorbi I, Floratos A, Stammschulte T, Gundert-Remy U, Nelson MR, Aithal GP, Daly AK; International Drug-induced Liver Injury Consortium (iDILIC). HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury. Pharmacogenet Genomics. 2016 May;26(5):218-24. [PubMed]

Schirmer JH, Bremer JP, Moosig F, Holle JU, Lamprecht P, Wieczorek S, Haenisch S, Cascorbi I. Cyclophosphamide treatment-induced leukopenia rates in ANCA-associated vasculitis are influenced by variant CYP450 2C9 genotypes. Pharmacogenomics. 2016 Mar;17(4):367-74. Epub 2016 Feb 19. [PubMed]

Zingler G, Hermann B, Fischer T, Herdegen T. Cardiovascular adverse events by non-steroidal anti-inflammatory drugs: when the benefits outweigh the risks. Expert Rev Clin Pharmacol. 2016 Sep 8:1-14. [Epub ahead of print]

 

2015

Beck-Broichsitter BE, Werk AN, Smeets R, Gröbe A, Heiland M, Cascorbi I, Wiltfang J, Häsler R, Becker ST. Targeting gene expression during the early bone healing period in the mandible: A base for bone tissue engineering. J Craniomaxillofac Surg. 2015;43:1452-60. [PubMed]

Bruckmueller H, Werk AN, Renders L, Feldkamp T, Tepel M, Borst C, Caliebe A, Kunzendorf U, Cascorbi I. Which genetic determinants should be considered for tacrolimus dose optimization in kidney transplantation? A combined analysis of genes affecting the CYP3A locus. Ther Drug Monit.  2015;37:288-95 [PubMed]

Cascorbi I.Pharmacological treatment of pain: future trends and novel insights. Clin Pharmacol Ther. 2015;97:104-8 [PubMed]

Drube S, Weber F, Loschinski R, Beyer M, Rothe M, Rabenhorst A, Göpfert C, Meininger I, Diamanti MA, Stegner D, Häfner N, Böttcher M, Reinecke K, Herdegen T, Greten FR, Nieswandt B, Hartmann K, Krämer OH, Kamradt T. Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells. Neurobiol Dis. 2015;77:127-40. [PubMed]

Haroun F, Al-Shaar L, Habib RH, El-Saghir N, Tfayli A, Bazarbachi A, Salem Z, Shamseddine A, Taher ACascorbi I, Zgheib NK. Effects of CYP2B6 genetic polymorphisms in patients receiving cyclophosphamide combination chemotherapy for breast cancer.Cancer Chemother Pharmacol. 2015;75:207-14 [PubMed]

Haenisch S, Zhao Y, Chhibber A, Kaiboriboon K, Do LV, Vogelgesang S, Barbaro NM, Alldredge BK, Lowenstein DH, Cascorbi I, Kroetz DL. SOX11 identified by target gene evaluation of miRNAs differentially expressed in focal and non-focal brain tissue of therapy-resistant epilepsy patients. Oncotarget. 2015;10:5354-68.[PubMed]

Iden T, Horn EP, Bein B, Böhm R, Beese J, Höcker J. Intraoperative temperature monitoring with zero heat flux technology (3M SpotOn sensor) in comparison with sublingual and nasopharyngeal temperature: An observational study. Eur J Anaesthesiol. 2015;32:387-91. [PubMed]

Koinzer S, Reinecke K, Herdegen T, Roider J, Klettner A.Oxidative Stress Induces Biphasic ERK1/2 Activation in the RPE with Distinct Effects on Cell Survival at Early and Late Activation. Curr Eye Res. 2015;40:853-7 [PubMed]

Menzfeld C, John M, van Rossum D, Regen T, Scheffel J, Janova H, Götz A, Ribes S, Nau R, Borisch A, Boutin P, Neumann K, Bremes V, Wienands J, Reichardt HM, Lühder F, Tischner D, Waetzig V, Herdegen T, Teismann P, Greig I, Müller M, Pukrop T, Mildner A, Kettenmann H, Brück W, Prinz M, Rotshenker S, Weber MS, Hanisch UK. Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism.Glia. 2015;63:1083-99 [PubMed]

Schmedt Auf der Günne W1, Zhao Y, Hedderich J, Gohlke P, Culman J. Omapatrilat: penetration across the blood-brain barrier and effects on ischaemic stroke in rats. Naunyn Schmiedebergs Arch Pharmacol.2015 Sep;388(9):939-51. Epub 2015 May 8. [PubMed]

Zhao Y, Lützen U, Fritsch J, Zuhayra M, Schütze S, Steckelings UM, Recanti C, Namsoleck P, Unger T, Culman J. Activation of intracellular angiotensin AT₂ receptors induces rapid cell death in human uterine leiomyosarcoma cells. Clin Sci (Lond). 2015;128:567-78. [PubMed]

 

 

2014

Antanavičiūtė I, Mildažienė V, Stankevičius E, Herdegen T, Skeberdis VA. Hyperthermia differently afffects connexin43 expression and gap junction permeability in skeletal myoblasts and HeLa cells. Mediators Inflamm. 2014; Epub ahead of print. [PubMed]

Bruhn O, Cascorbi I. Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance. Expert Opin Drug Metab Toxicol. 2014; Epub ahead of print. [PubMed]

Cascorbi I, Tyndale R. Progress in pharmacogenomics: bridging the gap from research to practice. Clin. Pharmacol Ther. 2014; 95:231-5. [PubMed]  

Daly AK, Cascorbi I. Opportunities and limitations: The value of pharmacogenetics in clinical practice. Br J Clin Pharmacol; 2014;77: 583-586. [PubMed]

Goldstein JI, Fredrik Jarskog L, Hilliard C, Alfirevic A, Duncan L, Fourches D, Huang H, Lek M, Neale BM, Ripke S, Shianna K, Szatkiewicz JP, Tropsha A, van den Oord EJ, Cascorbi I, Dettling M, Gazit E, Goff DC, Holden AL, Kelly DL, Malhotra AK, Nielsen J, Pirmohamed M, Rujescu D, Werge T, Levy DL, Josiassen RC, Kennedy JL, Lieberman JA, Daly MJ, Sullivan PF. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.Nat Commun. 2014; Epub ahead of print. [PubMed]

Haenisch S, Werk AN, Cascorbi I. MicroRNAs and their relevance to ABC transporters. Br J Clin Pharmacol; 2014 Epub ahead of print. [PubMed]

Haeusgen W, Tueffers L, Herdegen T, Waetzig V. Map2k4δ - Identification and functional characterization of a novel Map2k4 splice variant. Biochim Biophys Acta. 2014; 1843: 875-884. [PubMed]

Nies AT, Schaeffeler E, van der Kuip H, Cascorbi I, Bruhn O, Kneba M, Pott C, Hofmann U, Volk C, Hu S, Baker SD, Sparreboom A, Ruth P, Koepsell H, Schwab M. Cellular uptake of iImatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1). Clin Cancer Res. 2014; 20: 985-994. [PubMed]

Ott G, Reichmann D, Boerger C, Cascorbi I, Bittner F, Mendel RR, Kunze T, Clement B, Havemeyer A. Functional characterization of protein variants encoded by non-synonymous SNPs in MARC1 and MARC2 in healthy Caucasians. Drug Metab Dispos. 2014; 42: 718-725. [PubMed]

Reinecke K, Böhm R, Hean E, Cascorbi I, Herdegen T. Die Aufgaben der Transferasen. DAZ 48.

Reinecke K, Böhm R, Hean E, Cascorbi I, Herdegen T. CYP2C und CYPE1. DAZ 2014;

Sosna J, Voigt S, Mathieu S, Lange A, Thon L, Davarnia P, Herdegen T, Linkermann A, Rittger A, Chan FK, Kabelitz D, Schütze S, Adam D. TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. Cell Mol Life Sci. 2014; 71: 331-48. [PubMed]

Tortoriello G, Morris CV, Alpar A, Fuzik J, Shirran SL, Calvigioni D, Keimpema E, Botting CH, Reinecke K, Herdegen T, Courtney M, Hurd YL, Harkany T. Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG 10/stathmin-2 degradation pathway. EMBO J. 2014; 33: 668-685. [PubMed]

Werk AN, Bruckmueller H, Haenisch S, Cascorbi I. Genetic variants may play an important role in mRNA-miRNA interaction: evidence for haplotype-dependent downregulation of ABCC2 (MRP2) by miRNA-379. Pharmacogenet Genomics. 2014; 24: 283-91. [PubMed]

Werk AN, Cascorbi I. Functional Gene Variants of CYP3A4. ClinPharmacol Ther. 2014; 96: 340-348. [PubMed]

Werk AN, Lefeldt S, Bruckmueller H, Hemmrich-Stanisak G, Franke A, Roos M, Küchle C, Steubl D, Schmaderer C, Bräsen JH, Heemann U, Cascorbi I, Renders L. Identifikation and characterization of a defective CYP3A4 genotype in a kidney transplant patient with severely diminished tacrolismus clearance. Clin Pharmacol Ther. 2014; 95:416-22. [PubMed]

 

2013

Bär F, Bochmann W, Widok A, von Medem K, Pagel R, Hirose M, Yu X, Kalies K, König P, Böhm R, Herdegen T, Reinicke AT, Büning J, Lehnert H, Fellermann K, Ibrahim S, Sina C. Mitochondrial gene polymorphisms that protect mice from colitis. Gastro. 2013; 145: 1055-1063. [PubMed]

Cascorbi I. Overlapping effects of genetic variation and epigenetics on drug response: challenges of pharmacoepigenomics. Pharmacogenomics. 2013; 15: 1807-9. [PubMed]

Cascorbi I, Bruhn O, Werk A. Challenges in pharmacogenetics. Eur J Clin Pharmacol. 2013; 69: 17-23. [PubMed]

Cascorbi I, Flüh C, Remmler C, Haenisch S, Faltraco F, Grumbt M, Peters M, Brenn A, Thal D R, Warzok R F, Vogelsang S. Association of ATP-binding cassette transporter variants with the risk of Alzheimer`s disease. Pharmacogenomics. 2013; 14: 485-494. [PubMed]

Hartmann JT, Kollmannsberger C, Cascorbi I, Mayer F, Schittenhelm MM, Heeger S, Bokemeyer C. A phase I pharmacokinetic study of matuzumab in combination with paclitaxel in patients with EGFR-expressing advanced non-small cell lung cancer. Invest New Drugs. 2013; 31: 661-8. [PubMed]

Jensen-Kondering U, Böhm R. Asymmetrically hypointense veins on T2*w imaging and susceptibility-weighted imaging in ischemic stroke. World J Radiol. 2013; 5 : 156-165. [PubMed]

Kersting S, Reinecke K, Hilgert C, Janot M S, Haarmann E, Albrecht M, Müller A M, Herdegen T, Mittelkötter U, Uhl W, Chromik A M. Knockout of the c-Jun N-terminal Kinase 2 aggravates the development of mild chronic dextran sulfate sodium colitis independently of expression of intestinal cytokines TNFα, TGFBI, and IL-6. J of Inflamm Res. 2013; 6:13-23. [PubMed]

Kersting S, Behrendt V, Kersting J, Reinecke K, Hilgert C, Stricker I, Herdegen T, Janot M S, Uhl W, Chromik A M. The Impact of JNK inhibitor D-JNKI-I in a murine model of chronic colitis induced by dextran sulfate sodium. J of Inflamm Res. 2013; 6: 71-81. [PubMed]

Oberstadt MC, Bien-Möller S, Weitmann K, Herzog S, Hentschel K, Rimmbach C, Vogelsang S, Balz E, Fink M, Michael H, Zeden JP, Bruckmüller H, Werk AN, Cascorbi I, Hoffmann W, Rosskopf D, Schroeder HW, Kroemer HK. Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme. BMC Cancer 2013; 13: 617. [PubMed]

Reinecke K, Herdegen T, Eminel S, Aldenhoff JB, Schiffelholz T. Knockout of c-Jun N-terminal kinases 1, 2 or 3 isoforms induces behavioural changes. Behav Brain Res. 2013; 245: 88-95. [PubMed]

Verhoef TI, Ragia G, de Boer A, Barallon R, Kolovou G, Kolovou V, Konstantinides S, Le Cessie S, Maltezos E, van der Meer FJ, Redekop WK, Remkes M, Rosendaal FR, van Schie RM, Tavridou A, Tziakas D, Wadelius M, Maolopoulos VG, Maitland-van der Zee AH, EU-PACT Group. A randomized trial of genotype-guided dosing of acenocoumarol and phenprocoumon. N Engl J Med. 2013; 369: 2304-12. [PubMed]

 

2012

Afsar NA, Ufer M, Haenisch S, Remmler C, Mateen A, Usmann A, Ahmed KZ, Ahmad HR, Cascorbi I. Relationship of drug metabolizing enzyme genotype to plasma levels as well as myelotoxicity of cyclophosphamide in breast cancer patients. Eur J Clin Pharmacol.. 2012; 68: 389-395. [PubMed]

Böhm R, Höcker J, Cascorbi I, Herdegen T. Open Vigil-free eyeballs on AERS pharmacovigilance data. Nat Biotechnol. 2012; 30: 137-138. [PubMed]

Culman J, Nguyen-Ngoc M, Glatz T, Gohlke P, Herdegen T, Zhao Y. Treatment of rats with pioglitazone in the reperfusion phase of focal cerebral ischemia: a preclinical stroke trial. Exp Neurol.. 2012; 238: 243-253. [PubMed]

Fox JC, Daly A, Cascorbi I, Alfirevic A, Linden H, Maitland-van der Zee AH. 5th Anniversary meeting of the European Research Network Pharmacogenetics / Pharmacogenomics. 8.-9. December 2011, Utrecht, The Netherlands. Pharmacogenomics. 2012; 13: 747-749. [PubMed]

Griesinger G, Dafopoulos K, Buendgen N, Cascorbi I, Georgoulias P, Zavos A, Messini CI, Messinis IE. Elimination half-life of anti-Mullerian hormone. J Clin Endocrinol Metab. 2012; 97: 2160-2163. [PubMed]

Haenisch S, Cascorbi I. miRNAs as mediators of drug resistance. Epigenomics. 2012; 4: 369-381. [PubMed]

Höcker J, Bein B, Böhm R, Steinfath M, Scholz J, Horn EP. Correlation, accuracy, precision and practicability of perioperative measurement of sublingual temperature in comparison with tympanic membrane temperature in awake and anaesthetised patients. European Journal of Anaesthesiology. 2012; 29: 70-74. [PubMed]

Horn EP, Bein B, Böhm R, Steinfath M, Sahili N, Höcker J. The effect of short time periods of pre-operative warming in the prevention of peri-operative hypothermia. Anaesthesia. 2012; 67: 612-617. [PubMed]

Jung S, Sönnichsen FD, Hung CW, Tholey A, Boidin-Wichlacz C, Häusgen W, Gelhaus C, Desel C, Podschun R, Wätzig V, Tasiemski A, Leippe M, Grötzinger J. Macin family of antimicrobial proteins combines antimicrobial and nerve repair activities. Journal of Biological Chemistry. 2012; 287: 14246-14258. [PubMed]

Krell J, Frampton AE, Cascorbi I, Werk A, Stebbing J. Highlights from the latest articles in breast cancer pharmacogenomics. Pharmacogenomics. 2012; 13: 645-649. [PubMed]

May D, Baastrup J, Nientit MR, Binder A, Schunke M, Baron R, Cascorbi I. Differential Expression and Functionality of TRPA1 Protein Genetic Variants in Conditions of Thermal Stimulation. J Biol Chem. 2012; 287: 27087-27094. [PubMed]

Reinecke K, Eminel S, Dierck F, Roessner W, Kersting S, Chromik AM, Gavrilova O, Laukevicience A, Leuschner I, Wätzig V, Rosenstiel P, Herdegen T, Sina C. The JNK inhibitor XG-102 protects against TNBS-induced colitis. Plos One. 2012; 3 [Epub]. [PubMed]

Ruff CA, Staak N, Patodia S, Kaswich M, Rocha-Ferreira E, Da Costa C, Brecht S, Makwana M, Fontana X, Hristova M, Rumajogee P, Galiano M, Bohatschek M, Herdegen T, Behrens A, Raivich G. Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate. J Neurochem. 2012; 121: 607-618. [PubMed]

Schaper C, Höcker J, Böhm R, Roeder T, Bein B. The shaker Potassium channel is no target for xenon anesthesia in short-sleeping Drosophila melanogaster mutants. Scientific World Journal; 2012 Epub 2012 Jun 18. [PubMed]

Schlusselhuber M, Jung S, Bruhn O, Goux D, Leippe M, Leclercq R, Laugier C, Grötzinger J, Cauchard J. In vitro potential of equine DEFA1 and eCATH1 as alternative antimicrobial drugs in rhodococcosis treatment. Antimicrob Agents Chemother. 2012; 56:1749-55. [PubMed]

Tauer U, Zhao Y, Hunt SP, Culman J. Are biological actions of neurokinin A in the adult brain mediated by a cross-talk between the NK1 and NK2 receptors? Neuropharmacology. 2012; 63:958-965. [PubMed]

Turrini E, Haenisch S, Laechelt S, Diewock T, Bruhn O, Cascorbi I. MicroRNA profiling in K-562 cells under imatinib treatment: influence of miR-212 and miR-328 on ABCG2 expression. Pharmacogenet Genomics 2012; 22: 198-205. [PubMed]

Werk AN, Cascorbi I. Conference Scene: Pharmacogenomic highlights of the DGPT Annual Congress. Pharmacogenomics. 2012; 13: 997-999. [PubMed]

Zhao Y, Spigolon G, Bonny C, Culman J, Vercelli A, Herdegen T. The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria. Mol Cell Neurosci. 2012; 49: 300-310. [PubMed]

 

2011

Afsar NA, Ufer M, Haenisch S, Remmler C, Mateen A, Usman A, Ahmed KZ, Ahmad HR, Cascorbi I. Relationship of drug metabolizing enzyme genotype to plasma levels as well as myelotoxicity of cyclophosphamide in breast cancer patients. Eur J Clin Pharmacol. 2011 [Epub ahead of print] [PubMed]

Athanasiou M C, Dettling M, Cascorbi I, Mosyagin I, Salisbury B A, Pierz K A, Zou W, Whalen H, Malhotra A K, Lencz T, Gerson S L, Kane J M, Reed C R. (2011) Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis. J.Clin.Psychiatry.;72: 458-463. [PubMed]

Binder A, May D, Baron R, Maier C, Tolle TR, Treede RD, Berthele A, Faltraco F, Flor H, Gierthmühlen J, Haenisch S, Huge V, Magerl W, Maihöfner C, Richter H, Rolke R, Scherens A, Uceyler N, Ufer M, Wasner G, Zhu J, Cascorbi I (2011). Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. PLoS.One.; 6: e17387. [PubMed]

Bruhn O, Grötzinger J, Cascorbi I, Jung S. (2011)Antimicrobial peptides and proteins of the horse - insights into a well-armed organism. Vet Res.;42:98. [PubMed]

Cascorbi I. (2011) P-glycoprotein: tissue distribution, substrates, and functional consequences of genetic variations. Handb.Exp.Pharmacol.;201:261-283. [PubMed]

Flachsbart F, Ufer M, Kleindorp R, Nikolaus S, Schreiber S, Nebel A. (2011) Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population. J Gerontol A Biol Sci Med Sci.;66:1186-1191. [PubMed]

Ghaddar F, Cascorbi I, Zgheib NK. (2011) Clinical implementation of pharmacogenetics:a nonrepresentative explorative survey to participants of World Pharma 2010. Pharmacogenomics.;12:1051-1059. [PubMed]

Haenisch S, Laechelt S, Bruckmueller H, Werk A, Noack A, Bruhn O, Remmler C,  Cascorbi I. (2011) Down-regulation of ATP-binding cassette C2 protein expression in HepG2 cells after rifampicin treatment is mediated by microRNA-379. Mol.Pharmacol.;80:314-20. [PubMed]

Haeusgen W, Herdegen T, Waetzig V. (2011) The bottleneck of JNK signaling: molecular and functional characteristics of MKK4 and MKK7. Eur J Cell Biol.;90:536-544. [PubMed]

Haeusgen W, Herdegen T, Waetzig V. (2011) MKK7γ1 reverses nerve growth factor signals: Proliferation and cell death instead of neuritogenesis and protection. Cell Signal.;23:1281-1290. [PubMed]

Laechelt, S., Turrini, E., Ruehmkorf, A., Siegmund, W., Cascorbi, I., and Haenisch, S. (2011) Impact of ABCC2 haplotypes on transcriptional and posttranscriptional gene regulation and function. Pharmacogenomics.J.; 11: 25-34. [PubMed]

Jensen-Kondering U, Böhm R, Höcker J, Ruhe R, Brdon J, Ulmer S, Herdegen T, Jansen O. 2011 [Epub ahead of print] Normal values of quantitative T2' in a spontaneously hypertensive stroke prone rat stem at 3T. Eur J Radiol. [PubMed]

Koehler K, Mielke K, Schunck M, Neumann C, Herdegen T, Proksch E. (2011) Distinct roles of JNK-1 and ERK-2 isoforms in permeability barrier repair and wound healing. Eur J Cell Biol.;90:565-571. [PubMed]

Staab CA, Stegk J P, Haenisch S, Neiss E, Kobsch K, Ebert B, Cascorbi I,  Maser E. (2011) Analysis of alternative promoter usage in expression of HSD11B1 including the development of a transcript-specific quantitative real-time PCR method. Chem.Biol.Interact.;191:104-112. [PubMed]

Tönges L, Planchamp V, Koch JC, Herdegen T, Bähr M, Lingor P. (2011) JNK isoforms differentially regulate neurite growth and regeneration in dopaminergic neurons In vitro. J Mol Neurosci.;45:284-293. [PubMed]

Ufer M, von Stülpnagel C, Muhle H, Haenisch S, Remmler C, Majed A, Plischke H, Stephani U, Kluger G, Cascorbi I. (2011) Impact of ABCC2 genotype on antiepileptic drug response in Caucasian patients with childhood epilepsy. Pharmacogen Genomics .; 21: 624-630. [PubMed]

Wruck CJ, Streetz K, Pavic G, Götz ME, Tohidnezhad M, Brandenburg LO, Varoga D, Eickelberg O, Herdegen T, Trautwein C, Cha K, Kan YW, Pufe T. (2011) Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter. J Biol Chem.;286:4493-4499. [PubMed]

Zhao Y, Spigolon G, Bonny C, Culman J, Vercelli A, Herdegen T. 2011 [Epub ahead of print] The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria. Mol Cell Neurosci. [PubMed]

Zuhayra M, Zhao Y, von Forstner C, Henze E, Gohlke P, Culman J, Lützen U. (2011) Activation of cerebral peroxisome proliferator-activated receptors γ (PPARγ) reduces neuronal damage in the substantia nigra after transient focal cerebral ischaemia in the rat. Neuropathol Appl Neurobiol.; 37:738-752. [PubMed]

2010

Afsar NA, Haenisch S, Mateen A, Usman A, Ufer M, Ahmed HR, Cascorbi I (2010) Genotype Frequences of selected Drug Metabolizing Enzymes and ABC Drug Transporters among Breast Cancer Patients on FAC Chemotherapy. Basic Clin Pharmacol Toxicol. 107:570-576. [PubMed]

Andus T, Kocjan A, Müser M, Baranovsky A, Mikhailova TL, Zvyagintseva TD, Dorofeyev AE, Lozynskyy YS, Cascorbi I, Stolte M, Vieth M, Dilger K, Mohrbacher R, Greinwald R (2010). On behalf of the International Salofalk Suppository OD Study Group Members of the International Salofalk Suppository OD Study Group are listed in the Appendix. Clinical trial: A novel high-dose 1 g mesalamine suppository (salofalk) once daily is as efficacious as a 500-mg suppository thrice daily in active ulcerative proctitis. Inflamm Bowel Dis. 16:1947-1956. [PubMed]

Birkett D, Brøsen K, Cascorbi I, Gustafsson LL, Maxwell S, Rago L, Sir Rawlins M, Reidenberg M, Sjöqvist F, Smith T, Thuerman P, Walubo A. (2010) Clinical pharmacology in research, teaching and health care: Considerations by IUPHAR, the International Union of Basic and Clinical Pharmacology. Basic Clin Pharmacol Toxicol. 2010 Jul;107(1):531-59. [PubMed]

Bokde AL, Lopez-Bayo P, Born C, Ewers M, Meindl T, Teipel SJ, Faltraco F, Reiser MF, Möller HJ, Hampel H. (2010) Alzheimer disease: functional abnormalities in the dorsal visual pathway. Radiology. 254(1):219-26. [PubMed]

Cascorbi I. (2010) ABC transporters in drug-refractory epilepsy: limited clinical significance of pharmacogenetics? Clin Pharmacol Ther. 87:15-8. [PubMed]

Cascorbi I. (2010) The promises of personalized medicine. Eur J Clin Pharmacol. 66(8):749-54. [PubMed]

Cascorbi I, Haenisch S. (2010). Pharmacogenetics of ATP-binding cassette transporters and clinical implications. Methods Mol Biol  596: 95-121. [PubMed]

Chromik AM, Huss S, Osseili H., Daigeler A, Kersting S, Sülberg D, Mittelkötter U, Herdegen T, Uhl W, Müller AM (2010). Oral administration of the anti-proliferative substance taurolidine has no impact on dextran sulfate sodium induced colitis-associated carcinogenesis in mice. J. Carcinog. 9: 5. [PubMed]

Culman J, Das G, Ohlendorf C, Haass M, Maser-Gluth C, Zuhayra M, Zhao Y, Itoi K (2010) Blockade of tachykinin NK(1)/NK(2) receptors in the brain attenuates the activation of CRH-neurones in the hypothalamic paraventricular nucleus and the sympathoadrenal and pituitary-adrenal responses to formalin-induced pain in the rat. J Neuroendocrinol. 22(5):467-76. [PubMed]

Drescher W, Lohse J, Varoga D, Buschmann C, Liebs T, Herdegen T, Hassenpflug J, Pufe T (2010). Enhanced constriction of supplying arteries - A mechanism of femoral head Necrosis in Wistar rats? Ann Anat. 192(1):58-61. [PubMed]                                                  

Glatz T , Stöck I, Nguyen-Ngoc M, Gohlke P, Herdegen T, Culman J, Zhao Y (2010) Peroxisome-proliferator-activated receptors gamma and peroxisome proliferator activated receptor beta/delta and the regulation of interleukin 1 receptor antagonist expression by pioglitazone in ischaemic brain. J. Hypertens. 28(7):1488-97. [PubMed]                   

Haeusgen W, Herdegen T, Waetzig V. (2010) Specific regulation of JNK signalling by the novel rat MKK7gamma1 isoform. Cell Signal. 22(11):1761-72. [PubMed]

Klettner A, Koinzer S, Waetzig V, Herdegen T, Roider J. (2010) Deferoxamine mesylate is toxic for retinal pigment epithelium cells in vitro, and its toxicity is mediated by p38. Cutan Ocul Toxicol. 29(2):122-9.  [PubMed]  

Langevin SM, Ioannidis JP, Vineis P, Taioli E.  (2010). Assessment of cumulative evidence for the association between glutathione S-transferase polymorphisms and lung cancer: application of the Venice interim guidelines. Genetic Susceptibility to Environmental Carcinogens group (GSEC). Pharmacogenet Genomics. 20:586-597. [PubMed]

Laechelt, S, Ruehmkorf, A., Siegmund, W, Cascorbi I, Haenisch, S. (2010) ABCC2 haplotypes and their influence on transcriptional and posttranscriptional gene regulation and talinolol transport. Pharmacogenom J 2010 Mar 30. [Epub ahead of print] [PubMed]

Liu JR, Zhao Y, Patzer A, Staak N, Boehm R, Deuschl G, Culman J, Bonny C, Herdegen T, Eschenfelder C. (2010) The c-Jun N-terminal kinase (JNK)  inhibitor XG-102 enhances the neuroprotection of hyperbaric oxygen after cerebral ischaemia in adult rats. Neuropath Appl Neuro 36(3):211-2. [PubMed]

Lutz U, Bittner , Ufer M., Lutz WK (2010). Quantification of cortisol and 6 beta-hydroxycortisol in human urine by LC-MS/MS, and gender-specific evaluation of the metabolic ratio as biomarker of CYP3A activity. J Chromat B, 878: 97-101. [PubMed]

Muszkat M,  Bialer O,  Blotnick S, Adar L, Xie HG, Ufer M, Cascorbi I, Caraco Y. (2010) Effects of folic acid supplementation on the pharmacokinetics and anticoagulant effect of warfarin: an open-label, prospective study of long-term administration in adults. Clin Ther 32(2): 347-56. [PubMed]       

Schmerbach K, Pfab T, Zhao Y, Culman J, Mueller S, Villringer A, Muller DN, Hocher B, Unger T, Thoene-Reineke C. (2010) Effects of aliskiren on stroke in rats expressing human renin and angiotensinogen genes. PLoS One 5(11):e15052. [PubMed]

Ufer M (2010) Comparative efficacy and safety of the novel oral anticoagulants dabigatran, rivaroxaban and apixaban in preclinical and clinical development. Thromb Haemost. 103(3):572-85. [PubMed]

 

2009

Albrecht L, Gabriel S, Packebusch A, Roth M, Beine KH, Faltraco F. (2009) Schwerhörigkeit und Gangunsicherheit ohne Schwindel. Radiologe. Dec;49(12):1136-40. [PubMed]              

Böhm R, Cascorbi I, Herdegen T (2009) Hypoglycemic risk of insulinotropic drugs. Med Monatsschr Pharm. Dec;32(12):453-8. [PubMed]

Brecht S, Waetzig V, Hidding U, Hanisch UK, Walther M, Herdegen T, Neiss WF (2009) FK506 protects against various immune responses and secondary degeneration following cerebral ischemia. Anat Rec (Hoboken) 292(12):1993-2001. [PubMed]

Cascorbi I, Haenisch S (2009) Pharmacogenetics of ATP-binding cassette transporters and clinical implications. Methods Mol Biol. 596:95-121. [PubMed]

Haeusgen W, Boehm R, Zhao Y, Herdegen T, Waetzig V (2009). Specific activities of individual c-Jun N-terminal kinases in the brain. Neuroscience 161: 951-999. [PubMed]

Herdegen T (2009). Survival in the brain. Med. Monatsschr. Pharm. 32: 4-6. [PubMed]

Ufer M., Häsler R., Jacobs G., Haenisch S., Lächelt S., Faltraco F., Sina, Ch., Rosenstiel, P., Nikolaus S., Schreiber S., Cascorbi, I. (2009) Decreased sigmoidal ABCB1 (P-glycoprotein) expression in ulcerative colitis is associated with disease activity. Pharmacogenomics 10 (12): 1941-1953. [PubMed]

Ufer M., Mosyagin I., Muhle H., Jacobsen T., Haenisch S., Häsler R., Faltraco F., Remmler C., von Spiczak S., Kroemer HK., Runge U., Boor R., Stephani U., Cascorbi I. (2009). Non-response to antiepileptic pharmacotherapy is associated with the ABCC2-24>T polymorphism in young and adult patients with epilepsy. Pharmacogenet Genom 19: 353-362. [PubMed]

van Schie RM, Cascorbi I, Maitland-van der Zee AH (2009) Conference Scene: Pharmacogenomics at the second PharmSciFair 2009: Adverse drug reactions and clinical implementation. Pharmacogenomics 10: 1389-1391. [PubMed]

Waetzig V, Wacker U, Haeusgen W, Björkblom B, Courtney MJ, Coffey ET, Herdegen T (2009) Concurrent protective and destructive signalling of JNK2 in neuroblastoma cells. Cell Signal 21: 873-880. [PubMed]

Zhao Y, Herdegen T (2009) Cerebral ischemia provokes a profound exchange of activated JNK isoforms in brain mitochondria. Mol. Cell. Neurosci. 41: 186-195. [PubMed]